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Year : 2012  |  Volume : 19  |  Issue : 3  |  Page : 127-132

Incidence of hepatotoxicity of highly active Antiretroviral Therapy in a Tertiary Health Centre in Nigeria.

1 Dept of Medicine, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
2 Dept of Medicine, Benue State University Teaching Hospital, Makurdi, Benue State, Nigeria
3 Dept of Medicine, University of Ilorin Teaching Hospital, Ilorin, Kwara State, Nigeria

Correspondence Address:
R A Ugiagbe
Dept of Medicine, University of Benin Teaching Hospital, Benin City, Edo State
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Source of Support: None, Conflict of Interest: None

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Aims and objectives: The aim of this study was to determine the incidence of hepatotoxicity of HAART in HIV infected patients in a tertiary health centre in Nigeria. Materials and Methods: This study was carried out on HIV patients on HAART attending infectious disease clinic, gastroenterology clinic or admitted into the medical wards of University of Benin Teaching Hospital. HAART-naive HIV patients were used as controls. A clinical evaluation and relevant laboratory investigations were done. Hepatotoxicity was defined using a standardised toxicity grade scale. Results: A total of 84 cases and 42 controls were studied. The mean ages were 35.2± 9.9years and 35.5±9.0 years for the cases and the controls respectively. Over 70% of the study population and controls were females. The overall incidence of hepatotoxicity was 17.9% and severe hepatotoxicity occurred in 10.7% of the patients. Alcohol use and being underweight were independent risk factors for hepatotoxicity. Conclusion: This prospective study clearly shows that there was appreciable hepatotoxicity associated with HAART in the study patients as found in other parts of the world. There is a need for regular monitoring of liver function in these patients because of the risk of hepatotoxicity.

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