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Year : 2011  |  Volume : 18  |  Issue : 3  |  Page : 186-190

The Effect of Palm Wine on Lipid Peroxidation and Antioxidant status of Rural dwellers in South West Nigeria

1 Department of Chemical Pathology, College of Health Science, Ladoke Akintola University of Technology, Osogbo, Nigeria
2 Department of Pathology, Federal Medical Centre, Owo, Ondo state; Department of Morbid Anatomy, University College Hospital, Ibadan, Oyo state, Nigeria

Correspondence Address:
P S Ogunro
Department of Chemical Pathology, College of Health Science, Ladoke Akintola University of Technology, Osogbo
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Source of Support: None, Conflict of Interest: None

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Aims and Objectives: To evaluate the levels/activities of antioxidants and lipid peroxidation in the blood of subjects that consumed palm wine on regular bases. Subjects and Methods: Sixty-four male volunteers between the ages of 30-70years were recruited for the study. The subjects were those that visited palm wine vendor outlet on regular basis at least for a minimum duration of 5 years, with daily intake of 80-160 gm of palm wine at a sitting for a minimum of 3 to 4 days per week. Plasma activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyltransferase (γ-GT); plasma concentration of total antioxidant status (TAS), Malonyldialdehyde ((MDA), selenium (Se) and erythrocyte glutathione peroxidase (GSH-Px) activity were determined. Results: The plasma activity of γ-GT and marker of lipid peroxidation (MDA) were significantly increased in subjects compared to the controls p<0.01. However, the erythrocyte scavenging antioxidant activity of GSH-Px and plasma Se for the subjects were significantly reduced compared to the controls p<0.05. Positive correlation was observed between MDA/ level of palm wine consumption (r= + 0.471, p<0.01), AST/ level of palm wine consumption (r= + 0.263, p<0.05) and γ- GT/level of palm wine consumption (r= + 0.518, p< 0.001) for the subjects. However, a negative correlation was obtained between GSH-Px/level of palm wine consumption (r= - 0.364, p<0.05) and selenium/ level of palm wine consumption (r=- 0.375, p<0.05) for the subjects. Conclusion: Reduced plasma Se and erythrocytes GSH-Px activity with increased plasma MDA in this study revealed that palm wine consumption may deplete the body's antioxidants against free radical attacks and render the body in a state of oxidative stress.

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