Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 511
  • Home
  • Print this page
  • Email this page
ARTICLE
Year : 2004  |  Volume : 11  |  Issue : 4  |  Page : 246-250

Short-term effect of oral contraceptive pills on some haemostatic parameters in healthy Nigerian women


Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin, Nigeria

Correspondence Address:
A S Babatunde
Department of Haematology and Blood Transfusion, University of Ilorin Teaching Hospital, Ilorin
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

The objective of this study was to determine the effect of low-dose combined oral contraceptive pill, Lo-femenal, on the following haemostatic parameters: platelet count (PC), prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen, of apparently healthy Nigerian women over a period of three months. A total of sixty-seven women were recruited for the study consisting of forty-seven subjects and twenty age-matched controls, who were aged between 17 and 37 years. All haemostatic parameters were determined using standard haematological techniques described by Dacie and Lewis, before, and three months after continuous use of oral contraceptive pills in the subjects. The same parameters were determined three months apart in control subjects who were on oral contraceptive pills. Statistical analysis of data was done using the chi-squared test and statistical significance was based on p value < 0.05. The mean values of platelet count and fibrinogen were significantly increased (p=0.0000 and 0.0003 respectively), while the PT and TT reduced significantly (p=0.007 and 0.0000 respectively) after three months of contraceptive use. There was no significant difference in the value of APTT (p=0.17) before and after oral contraceptive use. No differences were observed in the values in the controls. The findings in this study indicate some degree of pro-coagulant activity in the subjects, and the need to properly assess and monitor haemostatic parameters in pills users before commencement and while on them.


[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed322    
    Printed14    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal